P. Muzzin, J.-P. Revelli, F. Kühne, J.D. Gocayne, W.R. McCombie, J.C. Venter, J.-P. Giacobino, C.M. Fraser (1991) An adipose tissue-specific β-adrenergic receptor. Molecular cloning and down-regulation in obesity.J Biol Chem. 266, 24053-24058
41.
P. Muzzin, J.-P. Revelli, J.-P. Giacobino, C.M. Fraser (1992) Radioligand binding studies of the atypical β3-adrenergic receptor in rat brown adipose tissue using [3H]CGP 12177.FEBS Lett. 298, 162-164
42.
V. Vivat, J. Cohen-Tannoudji, J.-P. Revelli, P. Muzzin, J.-P. Giacobino, J.-P.Maltier, C.Legrand (1992) Progesterone transcriptionally regulates the β2-adrenergic receptor gene in pregnant rat myometrium.J Biol Chem. 267, 7975-7978
43.
J.-P. Revelli, P. Muzzin, J.-P. Giacobino (1992) Modulation in vivo of β-adrenergic-receptor subtypes in rat brown adipose tissue by the thermogenic agonist Ro 16-8714.Biochem J. 286, 743-746
44.
J.-P. Revelli, P. Muzzin, A. Paoloni, M. Moinat, J.-P. Giacobino (1993) Expression of the β3-adrenergic receptor in human white adipose tissue.J Mol Endocrinol. 10, 193-197
45.
L. Casteilla, P. Muzzin, J.-P. Revelli, D. Riquier, J.-P. Giacobino (1994) Expression of β1- and β3-adrenergic-receptor messages and adenylate cyclase b-adrenergic response in bovine perirenal adipose tissue during its transformation from brown into white fat. Biochem J. 297, 93-97
46.
P. Muzzin, O. Boss, N. Mathis, J.-P. Revelli, J.-P. Giacobino, K. Willcoks, G.T. Badman, B.C.C. Cantello, R.M. Hindley, M.A. Cawthorne (1994) Characterization of a highly specific new β3-adrenergic receptor radioligand: [3H]SB 206606.Mol Pharmacol. 46, 357-363
47.
S. Klaus, P. Muzzin, J.-P. Revelli, M.A. Cawthorn, J.-P. Giacobino, D. Ricquier (1995) Control of β3-adrenergic receptor gene expression in brown adipocytes in culture.Mol Cell Endocrinol. 109, 189-195
48.
M. Moinat, C. Deng, P. Muzzin, F. Assimacopoulos-Jeannet, J. Seydoux, A.G. Dulloo, J.-P. Giacobino (1995) Modulation of obese gene expression in rat brown and white adipose tissues.FEBS Lett. 373, 131-134
49.
J. Seydoux, P. Muzzin, M. Moinat, W. Pralong, L. Girardier, J.-P. Giacobino (1996) Adrenoceptor heterogeneity in human white adipocytes differentiated in culture as assessed by cytosolic free calcium measurements.Cell Signal. 8, 117-122
50.
C. Deng, A. Paoloni, F. Kühne, O. Boss, J.-P. Revelli, M. Moinat, M.A. Cawthorne, P. Muzzin, J.-P. Giacobino (1996) Respective degree of expression of β1-, β2- and β3-adrenoceptors in human brown and white adipose tissues.Br J Pharmacol. 118, 929-934
51.
R. Bruskiewich, T. Everson, L. Ma, L. Chan, M. Schertzer, J.-P. Giacobino, P. Muzzin, S. Woods (1996) Analysis of CA repeat polymorphisms places three human gene loci on the 8p linkage map.Cytogenet Cell Genet. 73, 331-333
52.
E. Kuto, J.-P. Giacobino (1996) Interaction of nuclear factors with the cAMP response elements of the human β3-adrenoceptor gene.Endocrine. 5, 265-274
53.
C. Deng, M. Moinat, L. Curtis, A. Nadakal, F. Preitner, O. Boss, F. Assimacopoulos-Jeannet, J. Seydoux, J.-P. Giacobino (1997) Effects of β-adrenoceptor subtype stimulation on obese gene messenger ribonucleic acid and on leptin secretion in mouse brown adipocytes differentiated in culture. Endocrinology. 138, 548-552
54.
O. Boss, S. Samec, A. Paoloni, C. Rossier, A. Dulloo, J. Seydoux, P. Muzzin, J.-P. Giacobino (1997) Uncoupling protein-3 : a new member of the mitochondrial carrier family with tissue-specific expression.FEBS Lett. 408, 39-42
55.
O. Boss, S. Samec, A. Dulloo, J. Seydoux, P. Muzzin, J.-P. Giacobino (1997) Tissue-dependent upregulation of rat uncoupling protein-2 expression in response to fasting or cold.FEBS Lett. 412, 111-114
56.
J.-P. Revelli, F. Preitner, Samec S., Muniesa P., Kuehne F., O. Boss, Vassali J.D., Dulloo A., Seydoux J., J.-P. Giacobino, Huarte J., Ody C. (1997) Targeted gene disruption reveals a leptin-independent role for the mouse β3-adrenoceptor in the regulation of body composition.J Clin Invest. 100, 1098-1106
57.
O. Boss, S. Samec, F. Kühne, P. Bijlenga, F. Assimacopoulos-Jeannet , J.Seydoux, J.-P. Giacobino, P. Muzzin (1998) Uncoupling protein-3 expression in rodent skeletal muscle is modulated by food intake but not by changes in environmental temperature.J Biol Chem. 273, 5-8
58.
E. Kuto, O. Boss, F. Levasseur, J.-P. Giacobino (1998) Quantification of the full length leptin receptor (OB-Rb) in human brown and white adipose tissue.Life Sci. 62, 445-451
59.
O. Boss, J.-P. Giacobino, P. Muzzin (1998) Genomic structure of the uncoupling protein-3 (UCP3) and its assignment to chromosome 11q13.Genomics . 47, 311-313
60.
O. Boss, S. Samec, D. Desplanches, M.H. Mayet, J. Seydoux, P. Muzzin, J.-P. Giacobino (1998) Effect of endurance training on the expression of the uncoupling proteins 1, 2 and 3 in rat.FASEB J. 12, 335-339
61.
A.J. Kauman, F. Preitner, D. Sarsero, P. Molenaar, J.-P. Revelli, J.-P. Giacobino (1998) (-)-CGP 12177 causes cardiostimulation and binds to cardiac putative β4-adrenoceptors in both wild type and β3-adrenoceptor knockout mice.Mol Pharmacol . 53, 670-675
62.
I. Cusin, K.E. Zakrzewska, O. Boss, P. Muzzin, J.-P. Giacobino, D. Ricquier, B. Jeanrenaud, F. Roner-Jeanrenaud (1998) Chronic central leptin infusion enhances insulin-stimulated glucose metabolism and favors the expression of uncoupling proteins.Diabetes . 47, 1014-1019
63.
O. Boss, E. Bobbioni-Harsch, F. Assimacopoulos-Jeannet, P. Muzzin, R. Munger, J.-P. Giacobino, A. Golay (1998) Uncoupling protein-3 expression in skeletal muscle and free fatty acids in obese humans.Lancet . 351, 1933
64.
F. Preitner, P. Muzzin, J.-P. Revelli, J. Seydoux, J. Galtsky, M. Berlan, M. Lafontan, J.-P. Giacobino (1998) Metabolic response to various β3-adrenoceptor agonists in β3-adrenoceptor knockout mice : Evidence for a new β-adrenergic receptor in brown adipose tissue.Br J Pharmacol. 124, 1684-1688
65.
J.F. Surmley, M.J. Voirol, F. Assimacopoulos-Jeanet, J.-P. Giacobino, E. Jéquier, R.C. Gaillard, L. Tappy (1998) Stimulation by leptin of 3H GDP binding to brown adipose tissue of fasted but not fed rats.Int J Obes. 22, 923-926
66.
H. Kageyama, A. Suga, M. Kashiba, J. Oka, T. Osaka, T. Hirano, K. Nemoto, Y. Namba, D. Ricquier, J.-P. Giacobino, S. Inoue (1998) Increased uncoupling protein-2 and -3 gene expressions in skeletal muscle of STZ-induced diabetic rats.FEBS Lett . 440, 450-453
67.
A. Lanni, L. Beneduce, A. Lombardi, M. Moreno, O. Boss, P. Muzzin, J.-P. Giacobino, F.Goglia (1999) Expression of uncoupling protein-3 and mitochondrial activity in the transition from hypothyroid to hyperthyroid state in rat skeletal muscle.FEBS Lett. 444, 250-254
68.
T. Grandi, P. Muzzin, J.-P. Giacobino, F. Sparatore (1999) Synthesis and pharmalogical investigation of new arylethanolamines as β3-adrenoceptor ligands.Pharm Pharmacol Comm. 5, 561-564
69.
J. Oostendorp, F. Preitner, J. Moffat, M. Jimenez, J.-P. Giacobino, P. Molenaar, A.J. Kaumann (2000) Contribution of β-adrenoceptor subtypes to relaxation of colon and oesophagus and pacemaker activity of ureter in wild type and β3-adrenoceptor knockout mice.Br J Pharmaol. 130, 747-758
70.
A.G. Comuzzie, L. Almasy, S.A. Cole, O. Boss, J.-P. Giacobino, P. Muzzin, M.P. Stern, J.W. MacCluer, J. Blangero, J.E. Hixson (2000) Linkage exclusion analysis of the chromosome 11 region containing UCP2 and UCP3 with obesity-related phenotypes in Mexican Americans.Int J Obes. 24, 1065-1068
71.
R. Ceddia, W.N. Wlliam Jr, F.B. Lima, P. Flandin, R. Curi, J.-P. Giacobino (2000) Leptin stimulates uncoupling protein-2 mRNA expression and Krebs cycle activity and inhibits lipid synthesis in isolated rat white adipocytes.Eur J Biochem. 267, 5952-5958
72.
M. Jimenez, R.A. Simonyan, R. Ceddia, J.-P. Giacobino, P. Muzzin, V. Skulachev (2001) Cold-induced changes in the energy coupling and the UCP3 level in rodent skeletal muscles.Biochim Biophys Acta. 1505, 271-279
73.
C.M. Lanouette, J.-P. Giacobino, L. Pérusse, M. Lacaille, C. Yvon, M. Chagnon, F. Kühne, C. Bouchard, P. Muzzin, Y.C. Chagnon (2001) Association between uncoupling protein 3 gene and obesity-related phenotypes in the Québec Family Study.Mol Med. 7, 433-441
74.
P. Schrauwen, M.K.C. Hesselink, I. Vaartjes, E.Kornips, W.H. Saris, J.-P. Giacobino, A.-P. Russell (2002) Effect of acute exercise on uncoupling protein 3 is a fat metabolism-mediated effect.Am J Physiol Endocrinol Metab. 282, E11-17
75.
A.-P. Russell, G. Wadley, R. Snow, J.-P. Giacobino, P. Muzzin, A. Garnham, D. Cameron-Smith (2002) Slow component of VO2 kinetics: the effect of training status, fibre type, UCP3 mRNA and citrate synthase activity.Int J Obes Relat Metab Disord. 26, 157-164
76.
C.M. Lanouette, Y.C. Chagnon, T. Rice, L. Pérusse, P. Muzzin, J.-P. Giacobino, J. Gagnon, J.H. Wilmore, A.S. Leon, J.S. Skinner, D.C. Rao, C. Bouchard (2002) Uncoupling protein 3 gene is associated with body composition changes with training in HERITAGE study.J Appl Physiol. 92, 111-1118
77.
M. Jimenez, C. Yvon, L. Lehr, B. Léger, P. Keller, A.-P. Russell, F. Kühne, P. Flandin, J.-P. Giacobino, P. Muzzin (2002) Expression of uncoupling protein-3 in subsarcolemmal and intermyofibrillar mitochondria of various mouse muscle types and its modulation by fasting.Eur J Biochem. 269, 2878-2884
78.
M. Jimenez, B. Léger, K. Canola, L. Lehr, P. Arboit, J. Seydoux, A.-P. Russell, J.-P. Giacobino, P. Muzzin, F. Preitner (2002) β1/β2/β3-adrenoceptor knockout mice are obese and cold-sensitive but have normal lipolytic responses to fasting.FEBS Lett. 530, 37-40
79.
M. Jimenez, G. Barbatelli, R. Allevi, S. Cinti, J. Seydoux, J.-P. Giacobino, P. Muzzin, F. Preitner (2003) β3-adrenoceptor knockout in C57BL/6J mice depresses the occurrence of brown adipocytes in white fat.Eur J Biochem. 270, 699-705
80.
A.-P. Russell, G. Wadley, M.K.C. Hesselink, G. Schaart, S. Lo, B. Léger, A. Garnham, E. Kornips, D. Cameron-Smith, J.-P. Giacobino, P. Muzzin, R. Snow, P. Schrauwen (2003) UCP3 protein expression is lower in type I, IIa and IIx muscle fiber types of endurance-trained compared to untrained subjects.Eur J Phyiol. 445, 563-569
81.
A.-P. Russell, E. Somm, M. Praz, A.Crettenand, O. Hartley, A. Melotti, J.-P. Giacobino, P. Muzzin, C. Gobelet, O. Deriaz (2003) UCP3 protein regulation in human skeletal muscle fibre types I, IIa and IIx is dependent on exercise intensity.J Physiol. 550, 855-861
82.
A.-P. Russell, G. Gastaldi, E. Bobbioni-Harsch, P. Arboit, C. Gobelet, O.Deriaz, A.Golay, J.L. Witzum, J.-P. Giacobino (2003) Lipid peroxidation in skeletal muscle of obese as compared to endurance-trained humans: a case of good vs. bad lipids?FEBS Lett. 551, 104-106
83.
A.-P. Russell, J. Feilchenfeldt, S. Schreiber, M. Praz, A.Crettenand, C. Gobelet, C.A. Meier, D.R. Bell, A. Kralli, J.-P. Giacobino, O. Deriaz (2003) Endurance training in humans leads to fiber type-specific increases in levels of peroxisome proliferator-activated receptor-γ coactivator-1 and peroxisome proliferator-activated receptor-α in skeletal muscle.Diabetes. 52, 2874-2881
84.
A.-P. Russell, P. Schrauwen, E. Somm, G. Gastaldi, M.K.C. Hesselink, G. Schaart, E. Kornips, S.K. Lo, D. Bufano, J.-P. Giacobino, P. Muzzin, M. Ceccon, C. Angelini, L. Vergani (2003) Decreased fatty acid beta-oxidation in riboflavin-responsive, multiple acylcoenzyme A dehydrogenase-deficient patients is associated with an increase in uncoupling protein-3.J Clin Endocrinol Metab. 88, 5921-5926
85.
L. Lehr, F. Kühne, P. Arboit, J.-P. Giacobino, F.Poulin, P. Muzzin, M. Jimenez (2004) Control of 4E-BP1 expression in mouse brown adipose tissue by the β3-adrenoceptor.FEBS Lett. 576, 179-182
86.
A.-P. Russell, E. Somm, R. Debigare, O. Hartley, D. Richard, G. Gastaldi, A. Melotti, A. Michaud, J.-P. Giacobino, P. Muzzin, P. LeBlanc, F.Maltais (2004) COPD results in a reduction in UCP3 long mRNA and UCP3 protein content in types I and IIa skeletal muscle fibers.J Cardiopulm Rehabil. 24, 332-339
87.
P. Keller, L. Lehr, J.-P. Giacobino, J.-P. Charnay, N. Giovannini, F. Assimacopoulos-Jeannet (2005) Cloning, ontogenesis, and localization of an atypical uncoupling protein 4 in Xenopus laevis.Physiol Genomics. 22, 339-345
88.
G. Tavernier, M. Jimenez, J.-P. Giacobino, N. Hulo, M. Lafontan, P. Muzzin, D.Langin (2005) Norepinephrine induces lipolysis in β1/β2/β3-adrenoceptor knockout mice.Mol Pharmacol. 68, 793-799
89.
P. Keller, V. Compan, J. Bockaert, J.-P. Giacobino, Y. Charnay, C. Bouras, F. Assimacopoulos-Jeannet (2006) Characterization and localization of cocaine- and amphetamine-regulated transcript (CART) binding sites.Peptides. 27, 1328-1334
90.
L. Lehr, K. Canola, C. Asensio, M. Jimenez, F. Kühne, J.-P. Giacobino, P. Muzzin (2006) The control of UCP1 is dissociated from that of PGC-1α or of mitochondriogenesis as revealed by a study using β-less mouse brown adipocytes in culture.FEBS Lett. 580, 4661-4666
91.
K. Brixius, W. Bloch, C. Ziskoven, B. Bölck, A. Napp, C. Pott, D. Steinritz, M. Jimenez, K. Addicks, J.-P. Giacobino, R.H. Schwinger (2006) β3-adrenergic eNOS stimulation in left ventricular murine myocardium.Can J Physiol Pharmacol. 84, 1051-1060
92.
D. Mainieri, J.-P. Montani, J. Seydoux, J.-P. Giacobino, O. Boss, A.G. Dulloo (2007) β-adrenergic control of stearoyl-CoA desaturase 1 repression in relation to sympathoadrenal regulation of thermogenesis.Int J Obes. 31, 378-381
93.
C. Ziskoven, S. Grafweg, B. Bölck, R.J. Wiesner, M. Jimenez, J.-P. Giacobino, W. Bloch, R.H. Schwinger, K. Brixius (2007) Increased Ca2+ sensitivity and protein expression of SERCA 2a in situations of chronic β3-adrenoceptor deficiency.Pflügers Arch. 453, 443-453
94.
T. Matsuura, Y. Li, J.-P. Giacobino, F.H. Fu, J. Huard (2007) Skeletal muscle fiber type conversion during the repair of mouse soleus: potential implications for muscle healing after injury.J Orthop Res. 25, 1534-150
95.
G. Gastaldi, A.-P. Russell, A. Golay, J.-P. Giacobino, F. Habicht, V. Barthassat, P. Muzzin, E. Bobbioni-Harsch (2007) Upregulation of peroxisome proliferator-activated receptor γ coactivator gene (PGC-1α) during weight loss is related to insulin sensitivity but not to energy expenditure.Diabetologia. 50, 2348-2355
96.
C.S. Asensio, D. Arsenijevic, L. Lehr, J.-P. Giacobino, P. Muzzin, F.Rohner-Jeanrenaud (2008) Effects of leptin on energy metabolism in β-less mice.Int J Obes. 32, 936-942
97.
M. Crisan, L. Casteilla, L. Lehr, M. Carmona, A. Paoloni, S. Yap, B. Sun, B. Léger, A. Logar, L. Pénicaud, P. Schrauwen, D. Cameron-Smith, A.-P. Russell, B. Péault, J.-P. Giacobino (2008) A reservoir of brown adipocyte progenitors in human skeletal muscle.Stem Cells. 26, 2425-33
98.
E. Somm, V.M. Schwitzgebel, D.M. Vauthay, E.J. Camm, C.Y. Chen, J.-P. Giacobino, S.V. Sizonenko, M.L. Aubert, P.S. Hüppi (2008) Prenatal nicotine exposure alters early pancreatic islet and adipose tissue development with consequences on the control of body weight and glucose metabolism later in life.Endocrinology. 149, 6289-99
99.
M.Crisan, S. Yap, L. Casteilla, C.W. Chen, M. Corselli, T.S Park, G. Andriolo, B. Sun, B. Zheng, L. Zhang, C. Norotte, P.N. Teng, J. Traas, R. Schugar, B.M. Deasy, S. Badylak, H.J. Bühring, J.-P. Giacobino, L. Lazzari, J. Huard, B. Péault (2008) A Perivascular Origin for Mesenchymal Stem Cells in Multiple Human Organs.Cell Stem Cell . 3, 301-313
100.
L. Lehr, K. Canola, B. Léger, J.-P. Giacobino (2009) Differentiation and characterization in primary culture of white adipose tissue brown adipocyte-like cells.Int J Obes. 33, 680-686
101.
B. Léger, R. Senese, A.W. Al-Khodairy, O. Dériaz , Ch. Gobelet, J.-P. Giacobino, A.-P. Russell (2009) Atrogin-1, MuRF1, and FoXO, as well as phosphorylated GSK-3beta and 4E-BP1 are reduced in skeletal muscle of chronic spinal cord-injured patients.Muscle nerve. 40, 69-78
102.
P. Flandin, L. Lehr, C. Asensio, J.-P. Giacobino, F. Rohner-Jeanrenaud, P. Muzzin, M. Jimenez (2009) Uncoupling protein-3 as a molecular determinant of the action of 3,5,3'-triiodothyronine on energy metabolism.Endocrine. 36, 246-254
103.
S. Cinti, G. Barbatelli, I. Murano, L. Madsen, Q. Hao, M. Jimenez, K. Kristiansen, J.-P. Giacobino, R. De Matteis (2010) The emergence of cold-induced brown adipocytes in mouse white fat depots is predominantly determined by white to brown adipocyte transdifferentiation.Am J Physiol Endocrinol Metab. 298, E1244-53
104.
S. Lee, S. Grafweg, T. Schneider, M. Jimenez, J.-P. Giacobino, A. Ghanem, K. Tiemann, W. Bloch, J. Müller-Ehmsen, R.H. Schwinger, K. Brixius (2010) Total β-adrenoceptor deficiency results in cardiac hypotrophy and negative inotropy.Physiol Res. 59 679-689
105.
A.-P. Russell, M. Crisan, B. Léger, M. Corselli, A.J. McAinch, P.E. O'Brien, D. Cameron-Smith, B. Péault, L. Casteilla, J.-P. Giacobino (2012) Brown adipocyte progenitor population is modified in obese and diabetic skeletal muscle.Int J Obes (Lond). 36 155-158
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M. Crisan, B. Zheng, E. Zambidis, S. Yap, M. Tavian, B. Sun, J.-P. Giacobino, L. Casteilla, J.Huard, B. Péault (2007) Blood vessels as a source of progenitor cells in human embryonic and adult life. In: Stem Cells and their Potential for Clinical Application. Chapter II. N.M. Bilko et al. Eds.. 137-147
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M. Crisan, J. Huard, B. Zheng, B. Sun, S. Yap, A. Logar, J.-P. Giacobino, L. Casteilla, B. Péault (2008) Purification and culture of human blood vessel-associated progenitor cells.Curr Protoc Stem Cell Biol. Chapter 2:Unit 2B.2.1-2B.2.13.
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