A.J. Kauman, F. Preitner, D. Sarsero, P. Molenaar, J.-P. Revelli, J.-P. Giacobino (1998) (-)-CGP 12177 causes cardiostimulation and binds to cardiac putative β4-adrenoceptors in both wild type and β3-adrenoceptor knockout mice.Mol Pharmacol . 53, 670-675
99.
M.Crisan, S. Yap, L. Casteilla, C.W. Chen, M. Corselli, T.S Park, G. Andriolo, B. Sun, B. Zheng, L. Zhang, C. Norotte, P.N. Teng, J. Traas, R. Schugar, B.M. Deasy, S. Badylak, H.J. Bühring, J.-P. Giacobino, L. Lazzari, J. Huard, B. Péault (2008) A Perivascular Origin for Mesenchymal Stem Cells in Multiple Human Organs.Cell Stem Cell . 3, 301-313
97.
M. Crisan, L. Casteilla, L. Lehr, M. Carmona, A. Paoloni, S. Yap, B. Sun, B. Léger, A. Logar, L. Pénicaud, P. Schrauwen, D. Cameron-Smith, A.-P. Russell, B. Péault, J.-P. Giacobino (2008) A reservoir of brown adipocyte progenitors in human skeletal muscle.Stem Cells. 26, 2425-33
M.
O. Boss, L. Lehr, J.-P. Giacobino (2007) Adipose drug targets for obesity treatment. In: Obesity: Epidemiology, Pathophysiology, and Prevention. D. Bagchi and H.G. Preuss, Eds. Taylor & Francis Group, LLC, Boca Raton, F1. 177-196
49.
J. Seydoux, P. Muzzin, M. Moinat, W. Pralong, L. Girardier, J.-P. Giacobino (1996) Adrenoceptor heterogeneity in human white adipocytes differentiated in culture as assessed by cytosolic free calcium measurements.Cell Signal. 8, 117-122
40.
P. Muzzin, J.-P. Revelli, F. Kühne, J.D. Gocayne, W.R. McCombie, J.C. Venter, J.-P. Giacobino, C.M. Fraser (1991) An adipose tissue-specific β-adrenergic receptor. Molecular cloning and down-regulation in obesity.J Biol Chem. 266, 24053-24058
51.
R. Bruskiewich, T. Everson, L. Ma, L. Chan, M. Schertzer, J.-P. Giacobino, P. Muzzin, S. Woods (1996) Analysis of CA repeat polymorphisms places three human gene loci on the 8p linkage map.Cytogenet Cell Genet. 73, 331-333
73.
C.M. Lanouette, J.-P. Giacobino, L. Pérusse, M. Lacaille, C. Yvon, M. Chagnon, F. Kühne, C. Bouchard, P. Muzzin, Y.C. Chagnon (2001) Association between uncoupling protein 3 gene and obesity-related phenotypes in the Québec Family Study.Mol Med. 7, 433-441
101.
B. Léger, R. Senese, A.W. Al-Khodairy, O. Dériaz , Ch. Gobelet, J.-P. Giacobino, A.-P. Russell (2009) Atrogin-1, MuRF1, and FoXO, as well as phosphorylated GSK-3beta and 4E-BP1 are reduced in skeletal muscle of chronic spinal cord-injured patients.Muscle nerve. 40, 69-78
N.
M. Crisan, B. Zheng, E. Zambidis, S. Yap, M. Tavian, B. Sun, J.-P. Giacobino, L. Casteilla, J.Huard, B. Péault (2007) Blood vessels as a source of progenitor cells in human embryonic and adult life. In: Stem Cells and their Potential for Clinical Application. Chapter II. N.M. Bilko et al. Eds.. 137-147
105.
A.-P. Russell, M. Crisan, B. Léger, M. Corselli, A.J. McAinch, P.E. O'Brien, D. Cameron-Smith, B. Péault, L. Casteilla, J.-P. Giacobino (2012) Brown adipocyte progenitor population is modified in obese and diabetic skeletal muscle.Int J Obes (Lond). 36 155-158
89.
P. Keller, V. Compan, J. Bockaert, J.-P. Giacobino, Y. Charnay, C. Bouras, F. Assimacopoulos-Jeannet (2006) Characterization and localization of cocaine- and amphetamine-regulated transcript (CART) binding sites.Peptides. 27, 1328-1334
46.
P. Muzzin, O. Boss, N. Mathis, J.-P. Revelli, J.-P. Giacobino, K. Willcoks, G.T. Badman, B.C.C. Cantello, R.M. Hindley, M.A. Cawthorne (1994) Characterization of a highly specific new β3-adrenergic receptor radioligand: [3H]SB 206606.Mol Pharmacol. 46, 357-363
62.
I. Cusin, K.E. Zakrzewska, O. Boss, P. Muzzin, J.-P. Giacobino, D. Ricquier, B. Jeanrenaud, F. Roner-Jeanrenaud (1998) Chronic central leptin infusion enhances insulin-stimulated glucose metabolism and favors the expression of uncoupling proteins.Diabetes . 47, 1014-1019
87.
P. Keller, L. Lehr, J.-P. Giacobino, J.-P. Charnay, N. Giovannini, F. Assimacopoulos-Jeannet (2005) Cloning, ontogenesis, and localization of an atypical uncoupling protein 4 in Xenopus laevis.Physiol Genomics. 22, 339-345
72.
M. Jimenez, R.A. Simonyan, R. Ceddia, J.-P. Giacobino, P. Muzzin, V. Skulachev (2001) Cold-induced changes in the energy coupling and the UCP3 level in rodent skeletal muscles.Biochim Biophys Acta. 1505, 271-279
69.
J. Oostendorp, F. Preitner, J. Moffat, M. Jimenez, J.-P. Giacobino, P. Molenaar, A.J. Kaumann (2000) Contribution of β-adrenoceptor subtypes to relaxation of colon and oesophagus and pacemaker activity of ureter in wild type and β3-adrenoceptor knockout mice.Br J Pharmaol. 130, 747-758
85.
L. Lehr, F. Kühne, P. Arboit, J.-P. Giacobino, F.Poulin, P. Muzzin, M. Jimenez (2004) Control of 4E-BP1 expression in mouse brown adipose tissue by the β3-adrenoceptor.FEBS Lett. 576, 179-182
47.
S. Klaus, P. Muzzin, J.-P. Revelli, M.A. Cawthorn, J.-P. Giacobino, D. Ricquier (1995) Control of β3-adrenergic receptor gene expression in brown adipocytes in culture.Mol Cell Endocrinol. 109, 189-195
86.
A.-P. Russell, E. Somm, R. Debigare, O. Hartley, D. Richard, G. Gastaldi, A. Melotti, A. Michaud, J.-P. Giacobino, P. Muzzin, P. LeBlanc, F.Maltais (2004) COPD results in a reduction in UCP3 long mRNA and UCP3 protein content in types I and IIa skeletal muscle fibers.J Cardiopulm Rehabil. 24, 332-339
84.
A.-P. Russell, P. Schrauwen, E. Somm, G. Gastaldi, M.K.C. Hesselink, G. Schaart, E. Kornips, S.K. Lo, D. Bufano, J.-P. Giacobino, P. Muzzin, M. Ceccon, C. Angelini, L. Vergani (2003) Decreased fatty acid beta-oxidation in riboflavin-responsive, multiple acylcoenzyme A dehydrogenase-deficient patients is associated with an increase in uncoupling protein-3.J Clin Endocrinol Metab. 88, 5921-5926
100.
L. Lehr, K. Canola, B. Léger, J.-P. Giacobino (2009) Differentiation and characterization in primary culture of white adipose tissue brown adipocyte-like cells.Int J Obes. 33, 680-686
74.
P. Schrauwen, M.K.C. Hesselink, I. Vaartjes, E.Kornips, W.H. Saris, J.-P. Giacobino, A.-P. Russell (2002) Effect of acute exercise on uncoupling protein 3 is a fat metabolism-mediated effect.Am J Physiol Endocrinol Metab. 282, E11-17
60.
O. Boss, S. Samec, D. Desplanches, M.H. Mayet, J. Seydoux, P. Muzzin, J.-P. Giacobino (1998) Effect of endurance training on the expression of the uncoupling proteins 1, 2 and 3 in rat.FASEB J. 12, 335-339
F.
J.-P. Giacobino (1999) Effects of dietary deprivation, obesity and exercise on UCP3 mRNA levels. Int J Obes. 23, S60-63
96.
C.S. Asensio, D. Arsenijevic, L. Lehr, J.-P. Giacobino, P. Muzzin, F.Rohner-Jeanrenaud (2008) Effects of leptin on energy metabolism in β-less mice.Int J Obes. 32, 936-942
53.
C. Deng, M. Moinat, L. Curtis, A. Nadakal, F. Preitner, O. Boss, F. Assimacopoulos-Jeannet, J. Seydoux, J.-P. Giacobino (1997) Effects of β-adrenoceptor subtype stimulation on obese gene messenger ribonucleic acid and on leptin secretion in mouse brown adipocytes differentiated in culture. Endocrinology. 138, 548-552
83.
A.-P. Russell, J. Feilchenfeldt, S. Schreiber, M. Praz, A.Crettenand, C. Gobelet, C.A. Meier, D.R. Bell, A. Kralli, J.-P. Giacobino, O. Deriaz (2003) Endurance training in humans leads to fiber type-specific increases in levels of peroxisome proliferator-activated receptor-γ coactivator-1 and peroxisome proliferator-activated receptor-α in skeletal muscle.Diabetes. 52, 2874-2881
44.
J.-P. Revelli, P. Muzzin, A. Paoloni, M. Moinat, J.-P. Giacobino (1993) Expression of the β3-adrenergic receptor in human white adipose tissue.J Mol Endocrinol. 10, 193-197
67.
A. Lanni, L. Beneduce, A. Lombardi, M. Moreno, O. Boss, P. Muzzin, J.-P. Giacobino, F.Goglia (1999) Expression of uncoupling protein-3 and mitochondrial activity in the transition from hypothyroid to hyperthyroid state in rat skeletal muscle.FEBS Lett. 444, 250-254
77.
M. Jimenez, C. Yvon, L. Lehr, B. Léger, P. Keller, A.-P. Russell, F. Kühne, P. Flandin, J.-P. Giacobino, P. Muzzin (2002) Expression of uncoupling protein-3 in subsarcolemmal and intermyofibrillar mitochondria of various mouse muscle types and its modulation by fasting.Eur J Biochem. 269, 2878-2884
45.
L. Casteilla, P. Muzzin, J.-P. Revelli, D. Riquier, J.-P. Giacobino (1994) Expression of β1- and β3-adrenergic-receptor messages and adenylate cyclase b-adrenergic response in bovine perirenal adipose tissue during its transformation from brown into white fat. Biochem J. 297, 93-97
59.
O. Boss, J.-P. Giacobino, P. Muzzin (1998) Genomic structure of the uncoupling protein-3 (UCP3) and its assignment to chromosome 11q13.Genomics . 47, 311-313
93.
C. Ziskoven, S. Grafweg, B. Bölck, R.J. Wiesner, M. Jimenez, J.-P. Giacobino, W. Bloch, R.H. Schwinger, K. Brixius (2007) Increased Ca2+ sensitivity and protein expression of SERCA 2a in situations of chronic β3-adrenoceptor deficiency.Pflügers Arch. 453, 443-453
66.
H. Kageyama, A. Suga, M. Kashiba, J. Oka, T. Osaka, T. Hirano, K. Nemoto, Y. Namba, D. Ricquier, J.-P. Giacobino, S. Inoue (1998) Increased uncoupling protein-2 and -3 gene expressions in skeletal muscle of STZ-induced diabetic rats.FEBS Lett . 440, 450-453
52.
E. Kuto, J.-P. Giacobino (1996) Interaction of nuclear factors with the cAMP response elements of the human β3-adrenoceptor gene.Endocrine. 5, 265-274
71.
R. Ceddia, W.N. Wlliam Jr, F.B. Lima, P. Flandin, R. Curi, J.-P. Giacobino (2000) Leptin stimulates uncoupling protein-2 mRNA expression and Krebs cycle activity and inhibits lipid synthesis in isolated rat white adipocytes.Eur J Biochem. 267, 5952-5958
70.
A.G. Comuzzie, L. Almasy, S.A. Cole, O. Boss, J.-P. Giacobino, P. Muzzin, M.P. Stern, J.W. MacCluer, J. Blangero, J.E. Hixson (2000) Linkage exclusion analysis of the chromosome 11 region containing UCP2 and UCP3 with obesity-related phenotypes in Mexican Americans.Int J Obes. 24, 1065-1068
82.
A.-P. Russell, G. Gastaldi, E. Bobbioni-Harsch, P. Arboit, C. Gobelet, O.Deriaz, A.Golay, J.L. Witzum, J.-P. Giacobino (2003) Lipid peroxidation in skeletal muscle of obese as compared to endurance-trained humans: a case of good vs. bad lipids?FEBS Lett. 551, 104-106
64.
F. Preitner, P. Muzzin, J.-P. Revelli, J. Seydoux, J. Galtsky, M. Berlan, M. Lafontan, J.-P. Giacobino (1998) Metabolic response to various β3-adrenoceptor agonists in β3-adrenoceptor knockout mice : Evidence for a new β-adrenergic receptor in brown adipose tissue.Br J Pharmacol. 124, 1684-1688
43.
J.-P. Revelli, P. Muzzin, J.-P. Giacobino (1992) Modulation in vivo of β-adrenergic-receptor subtypes in rat brown adipose tissue by the thermogenic agonist Ro 16-8714.Biochem J. 286, 743-746
48.
M. Moinat, C. Deng, P. Muzzin, F. Assimacopoulos-Jeannet, J. Seydoux, A.G. Dulloo, J.-P. Giacobino (1995) Modulation of obese gene expression in rat brown and white adipose tissues.FEBS Lett. 373, 131-134
88.
G. Tavernier, M. Jimenez, J.-P. Giacobino, N. Hulo, M. Lafontan, P. Muzzin, D.Langin (2005) Norepinephrine induces lipolysis in β1/β2/β3-adrenoceptor knockout mice.Mol Pharmacol. 68, 793-799
L.
A.-P. Russell, J.-P. Giacobino (2002) Old and new determinants in the regulation of energy expenditure J Endocrinol Invest. 25, 862-866
98.
E. Somm, V.M. Schwitzgebel, D.M. Vauthay, E.J. Camm, C.Y. Chen, J.-P. Giacobino, S.V. Sizonenko, M.L. Aubert, P.S. Hüppi (2008) Prenatal nicotine exposure alters early pancreatic islet and adipose tissue development with consequences on the control of body weight and glucose metabolism later in life.Endocrinology. 149, 6289-99
42.
V. Vivat, J. Cohen-Tannoudji, J.-P. Revelli, P. Muzzin, J.-P. Giacobino, J.-P.Maltier, C.Legrand (1992) Progesterone transcriptionally regulates the β2-adrenergic receptor gene in pregnant rat myometrium.J Biol Chem. 267, 7975-7978
J.
P. Muzzin, J.-P. Giacobino (2001) Protéines découplantes et obésité. Métabolisme-Hormones-Nutrition. V, 204-206
O.
M. Crisan, J. Huard, B. Zheng, B. Sun, S. Yap, A. Logar, J.-P. Giacobino, L. Casteilla, B. Péault (2008) Purification and culture of human blood vessel-associated progenitor cells.Curr Protoc Stem Cell Biol. Chapter 2:Unit 2B.2.1-2B.2.13.
58.
E. Kuto, O. Boss, F. Levasseur, J.-P. Giacobino (1998) Quantification of the full length leptin receptor (OB-Rb) in human brown and white adipose tissue.Life Sci. 62, 445-451
41.
P. Muzzin, J.-P. Revelli, J.-P. Giacobino, C.M. Fraser (1992) Radioligand binding studies of the atypical β3-adrenergic receptor in rat brown adipose tissue using [3H]CGP 12177.FEBS Lett. 298, 162-164
50.
C. Deng, A. Paoloni, F. Kühne, O. Boss, J.-P. Revelli, M. Moinat, M.A. Cawthorne, P. Muzzin, J.-P. Giacobino (1996) Respective degree of expression of β1-, β2- and β3-adrenoceptors in human brown and white adipose tissues.Br J Pharmacol. 118, 929-934
C.
J.-P. Giacobino (1997) Role of the β3-adrenoceptor in the control of leptin expression. In: Obesity II. Recent advances in understanding and treatment, IBC library series, Southborough, MA/USA.
B.
J.-P. Giacobino (1996) Role of the β3-adrenoceptor in the control of leptin expression. Horm Metab Res. 28, 633-637
G.
J.-P. Giacobino (1999) Role of UCP3 in whole body thermogenesis. In: Progress in Obesity Research: 8. B.Guy-Grand and G. Ailhaud,Eds. John Libbey & Company Ltd, 8th International Congress on Obesity. 387-390
94.
T. Matsuura, Y. Li, J.-P. Giacobino, F.H. Fu, J. Huard (2007) Skeletal muscle fiber type conversion during the repair of mouse soleus: potential implications for muscle healing after injury.J Orthop Res. 25, 1534-150
75.
A.-P. Russell, G. Wadley, R. Snow, J.-P. Giacobino, P. Muzzin, A. Garnham, D. Cameron-Smith (2002) Slow component of VO2 kinetics: the effect of training status, fibre type, UCP3 mRNA and citrate synthase activity.Int J Obes Relat Metab Disord. 26, 157-164
65.
J.F. Surmley, M.J. Voirol, F. Assimacopoulos-Jeanet, J.-P. Giacobino, E. Jéquier, R.C. Gaillard, L. Tappy (1998) Stimulation by leptin of 3H GDP binding to brown adipose tissue of fasted but not fed rats.Int J Obes. 22, 923-926
68.
T. Grandi, P. Muzzin, J.-P. Giacobino, F. Sparatore (1999) Synthesis and pharmalogical investigation of new arylethanolamines as β3-adrenoceptor ligands.Pharm Pharmacol Comm. 5, 561-564
56.
J.-P. Revelli, F. Preitner, Samec S., Muniesa P., Kuehne F., O. Boss, Vassali J.D., Dulloo A., Seydoux J., J.-P. Giacobino, Huarte J., Ody C. (1997) Targeted gene disruption reveals a leptin-independent role for the mouse β3-adrenoceptor in the regulation of body composition.J Clin Invest. 100, 1098-1106
90.
L. Lehr, K. Canola, C. Asensio, M. Jimenez, F. Kühne, J.-P. Giacobino, P. Muzzin (2006) The control of UCP1 is dissociated from that of PGC-1α or of mitochondriogenesis as revealed by a study using β-less mouse brown adipocytes in culture.FEBS Lett. 580, 4661-4666
103.
S. Cinti, G. Barbatelli, I. Murano, L. Madsen, Q. Hao, M. Jimenez, K. Kristiansen, J.-P. Giacobino, R. De Matteis (2010) The emergence of cold-induced brown adipocytes in mouse white fat depots is predominantly determined by white to brown adipocyte transdifferentiation.Am J Physiol Endocrinol Metab. 298, E1244-53
D.
O. Boss, P. Muzzin, J.-P. Giacobino (1997) The uncoupling proteins, a review.In: Obesity II. Recent advances in understanding and treatment, IBC library series, Southborough, MA/USA.
E.
O. Boss, P. Muzzin, J.-P. Giacobino (1998) The uncoupling proteins, a review. Eur J Endocrinol. 139, 1-9
P.
J.-P. Giacobino, L. Casteilla (2010) Thermogenic brown adipocytes as new targets for the treatment of obesity in humans.Clin Lipidol. 5, 173-180
55.
O. Boss, S. Samec, A. Dulloo, J. Seydoux, P. Muzzin, J.-P. Giacobino (1997) Tissue-dependent upregulation of rat uncoupling protein-2 expression in response to fasting or cold.FEBS Lett. 412, 111-114
104.
S. Lee, S. Grafweg, T. Schneider, M. Jimenez, J.-P. Giacobino, A. Ghanem, K. Tiemann, W. Bloch, J. Müller-Ehmsen, R.H. Schwinger, K. Brixius (2010) Total β-adrenoceptor deficiency results in cardiac hypotrophy and negative inotropy.Physiol Res. 59 679-689
80.
A.-P. Russell, G. Wadley, M.K.C. Hesselink, G. Schaart, S. Lo, B. Léger, A. Garnham, E. Kornips, D. Cameron-Smith, J.-P. Giacobino, P. Muzzin, R. Snow, P. Schrauwen (2003) UCP3 protein expression is lower in type I, IIa and IIx muscle fiber types of endurance-trained compared to untrained subjects.Eur J Phyiol. 445, 563-569
81.
A.-P. Russell, E. Somm, M. Praz, A.Crettenand, O. Hartley, A. Melotti, J.-P. Giacobino, P. Muzzin, C. Gobelet, O. Deriaz (2003) UCP3 protein regulation in human skeletal muscle fibre types I, IIa and IIx is dependent on exercise intensity.J Physiol. 550, 855-861
76.
C.M. Lanouette, Y.C. Chagnon, T. Rice, L. Pérusse, P. Muzzin, J.-P. Giacobino, J. Gagnon, J.H. Wilmore, A.S. Leon, J.S. Skinner, D.C. Rao, C. Bouchard (2002) Uncoupling protein 3 gene is associated with body composition changes with training in HERITAGE study.J Appl Physiol. 92, 111-1118
H.
P. Muzzin, O. Boss, J.-P. Giacobino (1999) Uncoupling protein 3: its possible biological role and mode of regulation in rodents and humans.J Bioenerg Biomembr. 31, 467-473
54.
O. Boss, S. Samec, A. Paoloni, C. Rossier, A. Dulloo, J. Seydoux, P. Muzzin, J.-P. Giacobino (1997) Uncoupling protein-3 : a new member of the mitochondrial carrier family with tissue-specific expression.FEBS Lett. 408, 39-42
102.
P. Flandin, L. Lehr, C. Asensio, J.-P. Giacobino, F. Rohner-Jeanrenaud, P. Muzzin, M. Jimenez (2009) Uncoupling protein-3 as a molecular determinant of the action of 3,5,3'-triiodothyronine on energy metabolism.Endocrine. 36, 246-254
O. Boss, S. Samec, F. Kühne, P. Bijlenga, F. Assimacopoulos-Jeannet , J.Seydoux, J.-P. Giacobino, P. Muzzin (1998) Uncoupling protein-3 expression in rodent skeletal muscle is modulated by food intake but not by changes in environmental temperature.J Biol Chem. 273, 5-8
63.
O. Boss, E. Bobbioni-Harsch, F. Assimacopoulos-Jeannet, P. Muzzin, R. Munger, J.-P. Giacobino, A. Golay (1998) Uncoupling protein-3 expression in skeletal muscle and free fatty acids in obese humans.Lancet . 351, 1933
K.
J.-P. Giacobino (2002) Uncoupling proteins, leptin and obesity, an updated review. Ann N Y Acad Sci. 967, 398-402
95.
G. Gastaldi, A.-P. Russell, A. Golay, J.-P. Giacobino, F. Habicht, V. Barthassat, P. Muzzin, E. Bobbioni-Harsch (2007) Upregulation of peroxisome proliferator-activated receptor γ coactivator gene (PGC-1α) during weight loss is related to insulin sensitivity but not to energy expenditure.Diabetologia. 50, 2348-2355
92.
D. Mainieri, J.-P. Montani, J. Seydoux, J.-P. Giacobino, O. Boss, A.G. Dulloo (2007) β-adrenergic control of stearoyl-CoA desaturase 1 repression in relation to sympathoadrenal regulation of thermogenesis.Int J Obes. 31, 378-381
78.
M. Jimenez, B. Léger, K. Canola, L. Lehr, P. Arboit, J. Seydoux, A.-P. Russell, J.-P. Giacobino, P. Muzzin, F. Preitner (2002) β1/β2/β3-adrenoceptor knockout mice are obese and cold-sensitive but have normal lipolytic responses to fasting.FEBS Lett. 530, 37-40
91.
K. Brixius, W. Bloch, C. Ziskoven, B. Bölck, A. Napp, C. Pott, D. Steinritz, M. Jimenez, K. Addicks, J.-P. Giacobino, R.H. Schwinger (2006) β3-adrenergic eNOS stimulation in left ventricular murine myocardium.Can J Physiol Pharmacol. 84, 1051-1060
79.
M. Jimenez, G. Barbatelli, R. Allevi, S. Cinti, J. Seydoux, J.-P. Giacobino, P. Muzzin, F. Preitner (2003) β3-adrenoceptor knockout in C57BL/6J mice depresses the occurrence of brown adipocytes in white fat.Eur J Biochem. 270, 699-705
A.
J.-P. Giacobino (1995) β3-adrenoceptor: an update.Eur J Endocrinol. 132, 377-385