Obesity is a disease expanding exponentially in the world. It is considered a threat to the health because it predisposes in particular to diabetes, hypertension, arteriosclerosis and coronary heart disease...

β₃-adrenoceptor - UCP1 axis

Cloning (second) and characterization of the β₃-adrenoceptor.
First demonstration that it is an "adipose" receptor, down regulated in obesity...