General background  [Read more] 

Obesity is a disease expanding exponentially in the world. It is considered a threat to the health because it predisposes in particular to diabetes, hypertension, arteriosclerosis and coronary heart disease...

Overview of 003 contributions  [Close box] 
β3-adrenoceptor - UCP1 axis

Cloning (second) and characterization of the β3-adrenoceptor.
First demonstration that it is an "adipose" receptor, down regulated in obesity.
Search of its possible expression in human adipose tissues.
Effect of obesity, thyroid status and β3-adrenoceptor agonists on the β3-adrenoceptor expression.
Characterization of a new β3-adrenoceptor radioligand
Creation of a β3-adrenoceptor knockout mouse.
Demonstration that the β3-adrenoceptor is involved in the occurence of brown adipocytes in white fat (transdifferentiation?).
β3-adrenoceptor-leptin interaction.
Existence of a β4-adrenoceptor in heart, BAT and colon ?
Creation of a triple β123-adrenoceptor knockout mouse

Muzzin et al. (1991) An adipose tissue specific β -adrenergic receptor. Molecular cloning and down regulation in obesity. Journal of Biological Chemistry 266, 24053-24058.
Number of citations in November 2008: 149


Cloning (first) of UCP3.
Creation of UCP3 transfected cells.
Modulation studies in rodents. Effects of fasting, cold exposure, diabetes, thyroid status, leptin and training on UCP3 expression.
Modulation studies in humans. Effects of acute exercise, endurance training, various myopathies and obesity on UCP3 expression.
Genetic studies in humans.
Creation of transgenic models. Mice overexpressing UCP3 in their skeletal muscle and UCP3 knockout mice.

Boss et al. (1997) Uncoupling protein-3 : a new member of the mitochondrial carrier family with tissue-specific expression. FEBS Letters 408, 39-42.
Number of citations in November 2008: 710
Number of papers on UCP3 in November 2008: 686

UCP1 resurgence in humans?

Identification and prospective isolation of progenitor cells with a high potential for UCP1 expression in human skeletal muscle.
Detection of UCP1 in human muscle and control of its expression by the PPARγ agonist rosiglitazone.
Role of the progenitor cell reservoir in insulin resistance.

Crisan et al. (2008) A reservoir of brown adipocyte progenitors in human skeletal muscle. Stem Cells 26, 2425-2433


Université de Genève - Faculté de Médecine 
Centre Médical Universitaire  
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