| Cursus & Titles |
1999-2003
Travail de Diplôme en 2001:
"Analysis of the uncoupling protein-3 expression in mouse muscle in vivo and impact of its activity on cell metabolism in vitro"
PhD Thesis (Biology) in 2005:
"Conrol of UCP1expression in the adipose tissues; use of β1/β2/β3-adrenoceptor and 4E-BP1 knockout mouse models" |
| Bibliography |
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M. Jimenez, C. Yvon, L. Lehr, B. Léger, P. Keller, A.-P. Russell, F. Kühne, P. Flandin, J.-P. Giacobino, P. Muzzin (2002) Expression of uncoupling protein-3 in subsarcolemmal and intermyofibrillar mitochondria of various mouse muscle types and its modulation by fasting. Eur J Biochem. 269, 2878-2884 |
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M. Jimenez, B. Léger, K. Canola, L. Lehr, P. Arboit, J. Seydoux, A.-P. Russell, J.-P. Giacobino, P. Muzzin, F. Preitner (2002) β1/β2/β3-adrenoceptor knockout mice are obese and cold-sensitive but have normal lipolytic responses to fasting. FEBS Lett. 530, 37-40 |
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L. Lehr, F. Kühne, P. Arboit, J.-P. Giacobino, F.Poulin, P. Muzzin, M. Jimenez (2004) Control of 4E-BP1 expression in mouse brown adipose tissue by the β3-adrenoceptor. FEBS Lett. 576, 179-182 |
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P. Keller, L. Lehr, J.-P. Giacobino, J.-P. Charnay, N. Giovannini, F. Assimacopoulos-Jeannet (2005) Cloning, ontogenesis, and localization of an atypical uncoupling protein 4 in Xenopus laevis. Physiol Genomics. 22, 339-345 |
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L. Lehr, K. Canola, C. Asensio, M. Jimenez, F. Kühne, J.-P. Giacobino, P. Muzzin (2006) The control of UCP1 is dissociated from that of PGC-1α or of mitochondriogenesis as revealed by a study using β-less mouse brown adipocytes in culture. FEBS Lett. 580, 4661-4666 |
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O. Boss, L. Lehr, J.-P. Giacobino (2007) Adipose drug targets for obesity treatment. In: Obesity: Epidemiology, Pathophysiology, and Prevention. D. Bagchi and H.G. Preuss, Eds. Taylor & Francis Group, LLC, Boca Raton, F1. 177-196 |
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C.S. Asensio, D. Arsenijevic, L. Lehr, J.-P. Giacobino, P. Muzzin, F.Rohner-Jeanrenaud (2008) Effects of leptin on energy metabolism in β-less mice. Int J Obes. 32, 936-942 |
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M. Crisan, L. Casteilla, L. Lehr, M. Carmona, A. Paoloni, S. Yap, B. Sun, B. Léger, A. Logar, L. Pénicaud, P. Schrauwen, D. Cameron-Smith, A.-P. Russell, B. Péault, J.-P. Giacobino (2008) A reservoir of brown adipocyte progenitors in human skeletal muscle. Stem Cells. 26, 2425-33 |
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L. Lehr, K. Canola, B. Léger, J.-P. Giacobino (2009) Differentiation and characterization in primary culture of white adipose tissue brown adipocyte-like cells. Int J Obes. 33, 680-686 |
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P. Flandin, L. Lehr, C. Asensio, J.-P. Giacobino, F. Rohner-Jeanrenaud, P. Muzzin, M. Jimenez (2009) Uncoupling protein-3 as a molecular determinant of the action of 3,5,3'-triiodothyronine on energy metabolism. Endocrine. 36, 246-254 |
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