| Cursus & Titles |
1985-
PhD Thesis (Biochemistry) in 1990:
"Etude des sous-types du récepteur β-adrénergique dans le tissu adipeux brun de rat"
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| Bibliography |
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P. Muzzin, J.-P. Revelli, F. Kühne, J.D. Gocayne, W.R. McCombie, J.C. Venter, J.-P. Giacobino, C.M. Fraser (1991) An adipose tissue-specific β-adrenergic receptor. Molecular cloning and down-regulation in obesity. J Biol Chem. 266, 24053-24058 |
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P. Muzzin, J.-P. Revelli, J.-P. Giacobino, C.M. Fraser (1992) Radioligand binding studies of the atypical β3-adrenergic receptor in rat brown adipose tissue using [3H]CGP 12177. FEBS Lett. 298, 162-164 |
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V. Vivat, J. Cohen-Tannoudji, J.-P. Revelli, P. Muzzin, J.-P. Giacobino, J.-P.Maltier, C.Legrand (1992) Progesterone transcriptionally regulates the β2-adrenergic receptor gene in pregnant rat myometrium. J Biol Chem. 267, 7975-7978 |
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J.-P. Revelli, P. Muzzin, J.-P. Giacobino (1992) Modulation in vivo of β-adrenergic-receptor subtypes in rat brown adipose tissue by the thermogenic agonist Ro 16-8714. Biochem J. 286, 743-746 |
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J.-P. Revelli, P. Muzzin, A. Paoloni, M. Moinat, J.-P. Giacobino (1993) Expression of the β3-adrenergic receptor in human white adipose tissue. J Mol Endocrinol. 10, 193-197 |
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L. Casteilla, P. Muzzin, J.-P. Revelli, D. Riquier, J.-P. Giacobino (1994) Expression of β1- and β3-adrenergic-receptor messages and adenylate cyclase b-adrenergic response in bovine perirenal adipose tissue during its transformation from brown into white fat. Biochem J. 297, 93-97 |
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P. Muzzin, O. Boss, N. Mathis, J.-P. Revelli, J.-P. Giacobino, K. Willcoks, G.T. Badman, B.C.C. Cantello, R.M. Hindley, M.A. Cawthorne (1994) Characterization of a highly specific new β3-adrenergic receptor radioligand: [3H]SB 206606. Mol Pharmacol. 46, 357-363 |
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S. Klaus, P. Muzzin, J.-P. Revelli, M.A. Cawthorn, J.-P. Giacobino, D. Ricquier (1995) Control of β3-adrenergic receptor gene expression in brown adipocytes in culture. Mol Cell Endocrinol. 109, 189-195 |
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M. Moinat, C. Deng, P. Muzzin, F. Assimacopoulos-Jeannet, J. Seydoux, A.G. Dulloo, J.-P. Giacobino (1995) Modulation of obese gene expression in rat brown and white adipose tissues. FEBS Lett. 373, 131-134 |
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J. Seydoux, P. Muzzin, M. Moinat, W. Pralong, L. Girardier, J.-P. Giacobino (1996) Adrenoceptor heterogeneity in human white adipocytes differentiated in culture as assessed by cytosolic free calcium measurements. Cell Signal. 8, 117-122 |
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C. Deng, A. Paoloni, F. Kühne, O. Boss, J.-P. Revelli, M. Moinat, M.A. Cawthorne, P. Muzzin, J.-P. Giacobino (1996) Respective degree of expression of β1-, β2- and β3-adrenoceptors in human brown and white adipose tissues. Br J Pharmacol. 118, 929-934 |
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R. Bruskiewich, T. Everson, L. Ma, L. Chan, M. Schertzer, J.-P. Giacobino, P. Muzzin, S. Woods (1996) Analysis of CA repeat polymorphisms places three human gene loci on the 8p linkage map. Cytogenet Cell Genet. 73, 331-333 |
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O. Boss, S. Samec, A. Paoloni, C. Rossier, A. Dulloo, J. Seydoux, P. Muzzin, J.-P. Giacobino (1997) Uncoupling protein-3 : a new member of the mitochondrial carrier family with tissue-specific expression. FEBS Lett. 408, 39-42 |
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O. Boss, S. Samec, A. Dulloo, J. Seydoux, P. Muzzin, J.-P. Giacobino (1997) Tissue-dependent upregulation of rat uncoupling protein-2 expression in response to fasting or cold. FEBS Lett. 412, 111-114 |
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O. Boss, P. Muzzin, J.-P. Giacobino (1997) The uncoupling proteins, a review. In: Obesity II. Recent advances in understanding and treatment, IBC library series, Southborough, MA/USA. |
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O. Boss, S. Samec, F. Kühne, P. Bijlenga, F. Assimacopoulos-Jeannet , J.Seydoux, J.-P. Giacobino, P. Muzzin (1998) Uncoupling protein-3 expression in rodent skeletal muscle is modulated by food intake but not by changes in environmental temperature. J Biol Chem. 273, 5-8 |
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O. Boss, J.-P. Giacobino, P. Muzzin (1998) Genomic structure of the uncoupling protein-3 (UCP3) and its assignment to chromosome 11q13. Genomics . 47, 311-313 |
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O. Boss, S. Samec, D. Desplanches, M.H. Mayet, J. Seydoux, P. Muzzin, J.-P. Giacobino (1998) Effect of endurance training on the expression of the uncoupling proteins 1, 2 and 3 in rat. FASEB J. 12, 335-339 |
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I. Cusin, K.E. Zakrzewska, O. Boss, P. Muzzin, J.-P. Giacobino, D. Ricquier, B. Jeanrenaud, F. Roner-Jeanrenaud (1998) Chronic central leptin infusion enhances insulin-stimulated glucose metabolism and favors the expression of uncoupling proteins. Diabetes . 47, 1014-1019 |
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O. Boss, E. Bobbioni-Harsch, F. Assimacopoulos-Jeannet, P. Muzzin, R. Munger, J.-P. Giacobino, A. Golay (1998) Uncoupling protein-3 expression in skeletal muscle and free fatty acids in obese humans. Lancet . 351, 1933 |
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F. Preitner, P. Muzzin, J.-P. Revelli, J. Seydoux, J. Galtsky, M. Berlan, M. Lafontan, J.-P. Giacobino (1998) Metabolic response to various β3-adrenoceptor agonists in β3-adrenoceptor knockout mice : Evidence for a new β-adrenergic receptor in brown adipose tissue. Br J Pharmacol. 124, 1684-1688 |
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O. Boss, P. Muzzin, J.-P. Giacobino (1998) The uncoupling proteins, a review. Eur J Endocrinol. 139, 1-9 |
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A. Lanni, L. Beneduce, A. Lombardi, M. Moreno, O. Boss, P. Muzzin, J.-P. Giacobino, F.Goglia (1999) Expression of uncoupling protein-3 and mitochondrial activity in the transition from hypothyroid to hyperthyroid state in rat skeletal muscle. FEBS Lett. 444, 250-254 |
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T. Grandi, P. Muzzin, J.-P. Giacobino, F. Sparatore (1999) Synthesis and pharmalogical investigation of new arylethanolamines as β3-adrenoceptor ligands. Pharm Pharmacol Comm. 5, 561-564 |
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P. Muzzin, O. Boss, J.-P. Giacobino (1999) Uncoupling protein 3: its possible biological role and mode of regulation in rodents and humans. J Bioenerg Biomembr. 31, 467-473 |
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A.G. Comuzzie, L. Almasy, S.A. Cole, O. Boss, J.-P. Giacobino, P. Muzzin, M.P. Stern, J.W. MacCluer, J. Blangero, J.E. Hixson (2000) Linkage exclusion analysis of the chromosome 11 region containing UCP2 and UCP3 with obesity-related phenotypes in Mexican Americans. Int J Obes. 24, 1065-1068 |
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M. Jimenez, R.A. Simonyan, R. Ceddia, J.-P. Giacobino, P. Muzzin, V. Skulachev (2001) Cold-induced changes in the energy coupling and the UCP3 level in rodent skeletal muscles. Biochim Biophys Acta. 1505, 271-279 |
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C.M. Lanouette, J.-P. Giacobino, L. Pérusse, M. Lacaille, C. Yvon, M. Chagnon, F. Kühne, C. Bouchard, P. Muzzin, Y.C. Chagnon (2001) Association between uncoupling protein 3 gene and obesity-related phenotypes in the Québec Family Study. Mol Med. 7, 433-441 |
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P. Muzzin, J.-P. Giacobino (2001) Protéines découplantes et obésité. Métabolisme-Hormones-Nutrition. V, 204-206 |
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A.-P. Russell, G. Wadley, R. Snow, J.-P. Giacobino, P. Muzzin, A. Garnham, D. Cameron-Smith (2002) Slow component of VO2 kinetics: the effect of training status, fibre type, UCP3 mRNA and citrate synthase activity. Int J Obes Relat Metab Disord. 26, 157-164 |
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C.M. Lanouette, Y.C. Chagnon, T. Rice, L. Pérusse, P. Muzzin, J.-P. Giacobino, J. Gagnon, J.H. Wilmore, A.S. Leon, J.S. Skinner, D.C. Rao, C. Bouchard (2002) Uncoupling protein 3 gene is associated with body composition changes with training in HERITAGE study. J Appl Physiol. 92, 111-1118 |
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M. Jimenez, C. Yvon, L. Lehr, B. Léger, P. Keller, A.-P. Russell, F. Kühne, P. Flandin, J.-P. Giacobino, P. Muzzin (2002) Expression of uncoupling protein-3 in subsarcolemmal and intermyofibrillar mitochondria of various mouse muscle types and its modulation by fasting. Eur J Biochem. 269, 2878-2884 |
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M. Jimenez, B. Léger, K. Canola, L. Lehr, P. Arboit, J. Seydoux, A.-P. Russell, J.-P. Giacobino, P. Muzzin, F. Preitner (2002) β1/β2/β3-adrenoceptor knockout mice are obese and cold-sensitive but have normal lipolytic responses to fasting. FEBS Lett. 530, 37-40 |
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M. Jimenez, G. Barbatelli, R. Allevi, S. Cinti, J. Seydoux, J.-P. Giacobino, P. Muzzin, F. Preitner (2003) β3-adrenoceptor knockout in C57BL/6J mice depresses the occurrence of brown adipocytes in white fat. Eur J Biochem. 270, 699-705 |
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A.-P. Russell, G. Wadley, M.K.C. Hesselink, G. Schaart, S. Lo, B. Léger, A. Garnham, E. Kornips, D. Cameron-Smith, J.-P. Giacobino, P. Muzzin, R. Snow, P. Schrauwen (2003) UCP3 protein expression is lower in type I, IIa and IIx muscle fiber types of endurance-trained compared to untrained subjects. Eur J Phyiol. 445, 563-569 |
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A.-P. Russell, E. Somm, M. Praz, A.Crettenand, O. Hartley, A. Melotti, J.-P. Giacobino, P. Muzzin, C. Gobelet, O. Deriaz (2003) UCP3 protein regulation in human skeletal muscle fibre types I, IIa and IIx is dependent on exercise intensity. J Physiol. 550, 855-861 |
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A.-P. Russell, P. Schrauwen, E. Somm, G. Gastaldi, M.K.C. Hesselink, G. Schaart, E. Kornips, S.K. Lo, D. Bufano, J.-P. Giacobino, P. Muzzin, M. Ceccon, C. Angelini, L. Vergani (2003) Decreased fatty acid beta-oxidation in riboflavin-responsive, multiple acylcoenzyme A dehydrogenase-deficient patients is associated with an increase in uncoupling protein-3. J Clin Endocrinol Metab. 88, 5921-5926 |
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L. Lehr, F. Kühne, P. Arboit, J.-P. Giacobino, F.Poulin, P. Muzzin, M. Jimenez (2004) Control of 4E-BP1 expression in mouse brown adipose tissue by the β3-adrenoceptor. FEBS Lett. 576, 179-182 |
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A.-P. Russell, E. Somm, R. Debigare, O. Hartley, D. Richard, G. Gastaldi, A. Melotti, A. Michaud, J.-P. Giacobino, P. Muzzin, P. LeBlanc, F.Maltais (2004) COPD results in a reduction in UCP3 long mRNA and UCP3 protein content in types I and IIa skeletal muscle fibers. J Cardiopulm Rehabil. 24, 332-339 |
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G. Tavernier, M. Jimenez, J.-P. Giacobino, N. Hulo, M. Lafontan, P. Muzzin, D.Langin (2005) Norepinephrine induces lipolysis in β1/β2/β3-adrenoceptor knockout mice. Mol Pharmacol. 68, 793-799 |
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L. Lehr, K. Canola, C. Asensio, M. Jimenez, F. Kühne, J.-P. Giacobino, P. Muzzin (2006) The control of UCP1 is dissociated from that of PGC-1α or of mitochondriogenesis as revealed by a study using β-less mouse brown adipocytes in culture. FEBS Lett. 580, 4661-4666 |
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G. Gastaldi, A.-P. Russell, A. Golay, J.-P. Giacobino, F. Habicht, V. Barthassat, P. Muzzin, E. Bobbioni-Harsch (2007) Upregulation of peroxisome proliferator-activated receptor γ coactivator gene (PGC-1α) during weight loss is related to insulin sensitivity but not to energy expenditure. Diabetologia. 50, 2348-2355 |
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C.S. Asensio, D. Arsenijevic, L. Lehr, J.-P. Giacobino, P. Muzzin, F.Rohner-Jeanrenaud (2008) Effects of leptin on energy metabolism in β-less mice. Int J Obes. 32, 936-942 |
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P. Flandin, L. Lehr, C. Asensio, J.-P. Giacobino, F. Rohner-Jeanrenaud, P. Muzzin, M. Jimenez (2009) Uncoupling protein-3 as a molecular determinant of the action of 3,5,3'-triiodothyronine on energy metabolism. Endocrine. 36, 246-254 |
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